Two gay best friends take a trip to the Pines, a hamlet on New York’s Fire Island that’s a hotspot for queer culture. Over the course of their vacation, they party with friends and develop flirtations with two other, significantly wealthier vacationers.

The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

Rap superstar Saweetie hosts a celebration of sexual health and positivity, with help from expert educators, candid stand-ups and uninhibited puppets.