Uryuu Kamihate aims to enter medical school but finds his new foster home is a shrine where he must marry one of the three Amagami sisters and take over the temple.

In Fujisawa, Sakuta Azusagawa is in his second year of high school. Blissful days with his girlfriend and upperclassman, Mai Sakurajima, are interrupted by the appearance of his first crush, Shoko Makinohara.