Miles Morales catapults across the Multiverse, where he encounters a team of Spider-People charged with protecting its very existence. When the heroes clash on how to handle a new threat, Miles must redefine what it means to be a hero.

Joe Gardner is a middle school teacher with a love for jazz music. After a successful gig at the Half Note Club, he suddenly gets into an accident that separates his soul from his body and is transported to the You Seminar, a center in which souls develop and gain passions before being transported to a newborn child. Joe must enlist help from the other souls-in-training, like 22, a soul who has spent eons in the You Seminar, in order to get back to Earth.