Monster High 2 follows Clawdeen Wolf, Draculaura and Frankie Stein as they enter sophomore year at Monster High. The power of three is put to the test as they face even bigger challenges this year: new students, new powers, evolving friendships, and an even bigger threat that could not only tear their friendship apart, but could change the world forever.

Clawdeen Wolf, half human and half werewolf, has recently started attending Monster High, a school for monsters in all forms. After quickly befriending her classmates Frankie Stein and Draculaura, Clawdeen feels like she has finally found a place where she can truly be herself, or so she thinks. Soon, a devious plan to destroy Monster High threatens to reveal her real identity and Clawdeen must learn to embrace her true monster heart before it's too late.

Chelsea, a high school introvert, is abducted through a social media app and is forced to look like other girls Brad holds captive. Chelsea desperately attempts to persuade them to escape before they all become victims in his virtual reality filmed murders.