After a massacre, Tokiyuki flees with loyal retainers including Suwa Yorishige, who predicts Tokiyuki will rule Japan. Their priority is escaping enemy territory.

After teenager Ichigo Kurosaki acquires superpowers from wounded soul reaper Rukia Kuchiki, the two of them join forces to round up lost souls.

Ichigo Kurosaki's school is attacked by strange spirits called Unforgiven (Togabito), revealed to have escaped from Hell, and Rukia Kuchiki and Renji Abarai are sent to investigate. Ichigo's family is targeted by the Unforgiven, who are led by Shuren, and Ichigo's younger sister Yuzu Kurosaki is abducted. An Unforgiven named Kokut? saves Karin Kurosaki from being abducted as well, and convinces Ichigo to accompany him and the Soul Reapers to Hell to save her. When they are attacked by monsters called Kushan?da, the guardians of Hell, on the journey, Ichigo's Hollow mask begins to spontaneously manifest. Kokut? warns him to avoid using his mask lest he lose control and hollowfy entirely, and tells him that the Kushan?da torture Unforgiven for their sins by killing them, as Unforgiven continuously revive, and that spirits killed in Hell become Unforgiven themselves.

When the world is struck by a deadly pandemic that turns humans into zombies, Takashi Komuro and several of his classmates at Fujimi High School try to survive the apocalypse.