Madhuri Talkies is a Bhojpuri neo-noir set in the heartlands of Varanasi and Mughalsarai, where crimes against women and political tyranny rule the roost. One man sets forth on a deeply personal mission to avenge the love of his life and goes on a bloody rampage that puts the most powerful people of the city, from scheming politicians to police officers and the media, on high alert.

Mansoor, a reserved and reticent Pithoo (porter), helps pilgrims make an arduous journey upwards to the temple town. His world turns around when he meets the beautiful and rebellious Mukku who draws him into a whirlwind of intense love.

Hilarity ensues when a member of the Sharma family tethers between life and death as his relatives from across the country set up camp in Mumbai waiting for the inevitable that seems to have been delayed, indefinitely.