Samina was born into an educated Kashmiri Butt family in Lahore, but was raised in Karachi, Sindh Pakistan. After graduating in commerce she chose to pursue a career in acting. After many successful years of acting in television dramas and minor roles in television advertisements Samina was cast in starring roles in several films including Nazdikiyan, Mukhra, Bazar-e-Husn, Shaadi Mere Shohar Ki and Bulandi. She has traveled widely and has also performed in Oslo at The International Ibsen Festival. Her notable stage performances include productions such as Raaz-o-Niaz and Ibsen's A Doll's House. Television plays to her credit include Zindagi Gulzar Hai, Meri Zaat Zarra-e-Benishan, Rehaai, Durr-e-Shahwar, Dastaan and Karobi. Her first Hollywood film, The Valley, released on 2 March 2018.