Tathagata Mukherjee studied at the Baranagore Ramakrishna Mission Ashrama High School and thereafter studied drama at Rabindra Bharati university. He has done professional theater since 2005, during his childhood. He did three years yatra with Chapal Bhaduri.He started his career as a film actor in Laal Ronger Duniya in (2007). In 2008, he started his television career as a hero in a daily soap called Sada Patay Kalo Daag. After that he did many telefilms and soaps. Bou Kotha Kao (2009), became a turning point of his career. After that, he played lead characters in Payer Tolar Mati. Harano Sur, Kon Kanoner Phool, Sokhi, and Care Kori Na. He did cameo roles in agnipariksha and Tumi Asbe Bole. Tathagata played the lead role in Choukath. In 2014 Tathagata did two films back to back, superhit Badsahi angti and Force. His first Hindi film was The Best Seller. Tathagata essayed the role of reporter Debabrata Bose, alias, Dev in Raashi. He played the protagonist in mon niye kachakachi as Ranbir Kapoor, in 2015/16. In 2016 Mukherjee and his wife debolina dutta formed their production house. His first independent short film as director was Shuyopoka(2016). His next short film, Geodesy, selected for jio filmfare 2017 (Mumbai).The film was the only entry from west bengal in the finals. As an actor, he next worked on Parokiya. For the first time, Tathagata and Debleena are playing a married couple. The film is based on a short story written by the director in 2008. He is also shooting three TV series: Swapno Uran, Radha and Shree Krishna.In 2018 he made a horror short called Buno for Hoichoi.along side he made three music videos with national award winner music director mayookh bhoumik.Two of them "jingle bell qawali" and "Holi bol" got viral on the internet.Mr amitabh bacchan tweeted his video twice on the 31st 2017. Right now he is shooting a musical with national award winner singer Anupam roy,and his next Film "Unicorn". The film is about human liberation and teleportation.'Unicorn" has been shot for a period of over 8 months,at singapore,malasiya and andaman islands apart from kolkata.The film has under water portions which has been shot in indian ocean.Tathagata mukherjee himself was the underwater cinematographer and major portion of the film was shot by himself.